Abnormal uterine bleeding refers to abnormal bleeding from the uterus, which may occur with intermenstrual bleeding (spotting – metrorrhagia) or with bleeding greater than 80 ml. per cycle (menorrhagia)

The causes leading to uterine bleeding can be

• organic
• systemic
• dysfunctional

Organic causes of abnormal uterine bleeding

This group includes all atypical uterine bleeding in which an organic pathology responsible for the disorder can be identified, including:

• uterine polyps (cervical – endometrial)
• uterine myomas
• adenomyosis or uterine endometriosis
• endouterine devices (IUD)
• isthmocele (complication of caesarean sections)
• endometrial hyperplasia
• endometrial neoplasms

Systemic causes of abnormal uterine bleeding

The systemic diseases that most frequently lead to uterine bleeding are

• liver diseases
• thyroid diseases
• coagulation disorders
• taking certain medications

Dysfunctional causes of abnormal uterine bleeding

Dysfunctional causes affect all atypical uterine bleeding in which it is not possible to identify an organic pathology responsible for the abnormal blood loss.

Among the most frequent are

• typical cycle alterations in the period following menarche
• cycle alterations in the premenopausal period
• polycystic ovary
• stress
• obesity
• irregular estro-progestin intake
• progestin intake

Diagnostic investigations: what tests to do

The correct diagnosis of an abnormal uterine bleeding condition is made, first and foremost, through an anamnesis and gynaecological objective examination, with a pap smear performed.

Other examinations required are:

• β-hCG assay to rule out pregnancy
• haematochemical and hormonal examinations to rule out systemic causes (haemochromocytometric examination, thyroid hormone dosage, PT and PTT dosage to study the haemocoagulative system)
• transvaginal ultrasound
• hysteroscopy, which is nowadays the diagnostic gold standard, always preceded by transvaginal ultrasound.

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Source:

Pagine Mediche