Aetiological classification of hypertension

Hypertension is a constant, non-occasional state in which blood pressure at rest is higher than the physiological standard considered normal

The causes of high blood pressure can be classified from an aetiological point of view as

  • Systolic hypertension with increased differential pressure
  • Reduced arterial compliance (arteriosclerosis) and increased systolic output
  • Aortic insufficiency;
  • Thyrotoxicosis;
  • Primary hyperkinetic cardiac syndrome;
  • Arteriovenous fistula;
  • Botallo’s ductus pervio.
  • Systolic and diastolic hypertension (increased peripheral vascular resistance)
  • Unilateral and bilateral renal
  • Chronic pyelonephritis
  • Acute and chronic glomerulonephritis;
  • Polycystic kidney;
  • Nephrovascular stenosis; Renal infarction;
  • Other nephropathies (diabetic nephropathy, etc.);
  • Renin-secreting neoplasms.
  • Endocrine
  • Oral contraceptives;
  • Adrenal cortical hyperactivity;
  • Primary hyperaldosteronism (adenoma, micro-macro- nodular hyperplasia, glycocorticoid-sensitive hyperaldosteronism).
  • Cushing’s disease and syndrome.
  • Congenital or hereditary adrenogenital syndromes (17-α- and 11-ß hydroxylase deficiency)
  • Syndrome of apparent mineralocorticoid excess;
  • Pheochromocytoma;
  • Myxoedema;
  • Acromegaly;
  • Primary hyperparathyroidism;
  • Neurogenic
  • Psychogenic;
  • Diencephalic syndrome;
  • Familial dysautonomia (Riley-Day);
  • Polyneuritis (acute porphyria, Pb poisoning);
  • Increased intracranial pressure (acute);
  • Spinal cord section (acute);
  • Various
  • Coarctation of the aorta;
  • Increased intravascular volume (excessive transfusions, polycythaemia);
  • Panarteritis nodosa;
  • Hypercalcaemia;
  • Liddle’s syndrome;
  • Drugs and toxins
  • Mineralcorticoids and exogenous glycorticoids;
  • Liquorice and carbenoxolone;
  • Cyclosporine;
  • Sympathomimetics, tyramine, MAO inhibitors;
  • Substances of abuse (cocaine, etc.);
  • Anorectics;
  • Nasal decongestants;
  • Antidepressants;
  • Phenothiazine;
  • Erythropoietin;
  • Unknown aetiology
  • Essential hypertension (over 90% of cases)
  • Toxaemia gravidarum
  • Acute intermittent porphyria

The prevalence of secondary hypertension varies between 10 and 30% depending on the case series examined and the methods used to search for a possible cause of high blood pressure.

Renovascular hypertension is the most frequent secondary hypertension (7%) followed by hypertension of renoparenchymal origin and endocrine high blood pressure.

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