Depression increases the risk of cancer patients dying
Severe depression increases the chance of death in cancer patients by 86% in one study
Depression, often considered a purely mental disorder, has a profound impact on physical health. A recent study, conducted under the Mnesys project and coordinated by the University of Ferrara, has revealed a disturbing link between depression and increased risk of death, particularly in cancer patients. The results of the study are clear: the presence of severe depression increases the probability of death in patients with cancer by 86%, while for other chronic diseases this risk rises to 77%.
Why is depression so dangerous for health?
The biological mechanisms linking depression to an increased risk of death are complex and multifactorial. Depression triggers a chain reaction in the body, characterized by:
- Increased stress hormones: Cortisol and adrenaline, produced in excess during depressive episodes, weaken the immune system and increase chronic inflammation, promoting the development of cardiovascular diseases and other pathologies
- Reduced immune activity: Depression alters the function of immune cells, making the body more vulnerable to infections and cancer cells
- Sleep disturbances: Sleep disorders, common in depressed patients, impair tissue repair and increase the risk of developing chronic diseases
- Decreased appetite and altered metabolism: Loss of appetite and changes in metabolism can lead to malnutrition and general weakening of the body
The implications for health and well-being
These findings underline the importance of considering depression not only as a mental disorder, but as a disease that involves the whole organism. Early diagnosis and proper treatment of depression are essential to improve patients’ quality of life and reduce the risk of complications.
The role of the Mnesys project
The Mnesys project is making a significant contribution to depression research, funding innovative studies which aim to:
- Identify depression biomarkers: Through the analysis of blood, urine and other biological samples, researchers are trying to find biological markers that can help diagnose depression earlier and more accurately
- Develop new drugs and therapies: Numerous clinical studies are underway to evaluate the effectiveness of new drugs and therapies, such as transcranial magnetic stimulation and electroconvulsive therapy
- Personalize treatments: Using genetics, researchers are trying to identify the genetic factors that influence the response to antidepressant treatments in order to develop more effective and personalized therapies
The role of genetics
A study conducted under the Mnesys project has also shown that a genetic variant may affect the response to the most commonly used antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs). This discovery opens new perspectives for the development of personalized treatments, which can improve the effectiveness of therapies and reduce side effects.
Depression has a mental and physical impact
Depression is a complex disease that has a profound impact on physical and mental health. Scientific research is making great strides in understanding the mechanisms behind depression and developing new therapies. It is crucial that patients with depression receive early diagnosis and appropriate treatment to improve their quality of life and reduce the risk of complications.
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