What are cold agglutinins and why is the test performed to quantify their values in the blood?
Cold agglutinins are autoantibodies and are produced by the immune system. The presence of cold agglutinins causes red blood cells to aggregate upon exposure to cold temperatures.
In some cases their presence is associated with a rare autoimmune form of haemolytic anaemia due to a decrease in red blood cells and haemoglobin, known as cold agglutinin disease
In lesser amounts, cryoagglutinins may be present during infectious diseases such as syphilis, chickenpox, mononucleosis, etc., and in cases of neoplasms of the lymphatic system; in cases of haemoglobinuria and altered circulation in the body extremities.
This test is useful for investigating the cause of haemolytic anaemia and can contribute to the diagnosis of cold agglutinins disease
The test may be required in the presence of symptoms related to anaemia and/or pain, pallor, bluish discolouration of the fingers, toes and ear extremities after exposure to cold temperatures.
In addition, it can be used as an in-depth examination following the diagnosis of haemolytic anaemia.
What does the test result mean?
A positive result indicates the presence of cold agglutinin disease.
How is the test performed?
The test is performed by taking venous blood from the arm.
Is there any preparation required for the cold agglutinins test?
No, no special preparation is required for this test.
Please note that the results of the laboratory tests must be framed by the doctor, taking into account any medications taken, phytotherapeutic products and medical history.
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