Indima ebalulekileyo yeGuanine kwiDNA kunye neRNA
Ukufunyaniswa kokubaluleka kwenye yeNucleotides ezine ezisisiseko kuBomi
Yintoni iGuanine?
Enye yeebhloko ezine eziphambili zokwakha ze-DNA kunye ne-RNA yi iguanine. Yikhompawundi ekhethekileyo enenitrogen edityaniswa ne-adenine, icytosine, kunye ne-thymine (okanye i-uracil kwi-RNA) ukwenza ikhowudi yofuzo. Yintoni eyenza i-guanine ibe yinto ekhethekileyo yesakhiwo sayo esiyinkimbinkimbi: i-fusion ye-pyrimidine kunye ne-imidazole amakhonkco, ukudala i-purine compound. Ifomula yayo C5H5N5O.
IiPropati zoMzi kunye noLwakhiwo
IGuanine ibonakala njengomgubo omhlophe kwaye inendawo yokunyibilika ephezulu ngokumangalisayo, malunga ne-360°C. Oku kungenxa yokuba iikristale zayo zibanjwa kunye ngamabhondi e-hydrogen eyomeleleyo. Nangona inganyibiliki emanzini, i-guanine inokunyibilika kwi-acids diluted okanye iziseko. Ubunzima bayo bemolekyuli yi-151.13 g/mol, kwaye ubuninzi bayo obaliweyo buyi-2.200 g/cm³.
Umsebenzi webhayoloji kunye nezicelo
Ngaphandle kwe-guanine, ubomi ngebungekho. Yenza ibhondi eyomeleleyo kunye ne-cytosine kwi-DNA kunye ne-RNA ngokusebenzisa iibhondi ezintathu ze-hydrogen. Oku kuzinzisa isakhiwo esidumileyo se-helix ephindwe kabini kwaye siqinisekisa ukuphindaphindwa kwe-DNA echanekileyo. Kodwa imisebenzi ye-guanine ayipheleli apho. I-derivatives yayo, njenge-GTP (guanosine triphosphate), idlala indima ebalulekileyo kwiinkqubo zeselula ezifana nokubonisa kunye nokuveliswa kweeprotheni.
I-Guanine yeyeqela elibizwa ngokuba yi-purine bases, iinxalenye ezibalulekileyo ze-DNA kunye neemolekyuli ze-RNA.
Ibali lokuFumana
Kunyaka okude we-1844, i-chemist yaseJamani egama layo UJulius Bodo Unger okokuqala wafumanisa iguanine. Yintoni ekhethekileyo? Wayikhupha kwi-guano, kungoko igama layo. Ngokuhamba kwexesha, izazinzulu ziye zafunda okungakumbi ngendlela eyenziwe ngayo iguanine nendima yayo ebalulekileyo kwimfuza nakwibhayoloji yeemolekyuli.
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